Fibromyalgia Research

Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? A recent literature review was completed to show that there may be an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines. These scientists conclude this by analyzing literature about migraine headache, IBS and other related common fibromyalgia symptoms.

Online Seminars via New York Chiropractic College

New York Chiropractic College recently opened its Chiropractic Assistant school.  The first in the nation (probably the world!).  The school is based out of New Jersey but many of the classes are online.  I had the privilege of writing the courses for : domestic violence, professional ethics, how professionals can handle sexual assault cases,  legal issues and much more.

Other courses with NYCC also addresses addiction and nutrition and medical errors.

CBD and Pain Relief

Cannabidiol (CBD) oil is used by some people with chronic pain. CBD oil may reduce pain, inflammation, and overall discomfort related to a variety of health conditions. CBD oil is a product made from cannabis. It’s a type of cannabinoid, a chemical found naturally in marijuana and hemp plants. It doesn’t cause the “high” feeling often associated with cannabis, which is caused by a different type of cannabinoid called THC.

Studies on CBD oil and pain management have shown a great deal of promise. CBD can offer an alternative for people who have chronic pain and rely on more dangerous, habit-forming medications like opioids. But there needs to be more research in order to verify the pain-relieving benefits of CBD oil.

CBD products aren’t approved by the U.S. Food and Drug Administration (FDA) for any medical condition. They aren’t regulated for purity and dosage like other medications.

Keep reading to learn more about the potential benefits of CBD oil for pain. You can also talk with your doctor to see if it is an option for your condition.

CBD for chronic pain relief

Researchers think that CBD interacts with receptors in your brain and immune system. Receptors are tiny proteins attached to your cells that receive chemical signals from different stimuli and help your cells respond. This creates anti-inflammatory and painkilling effects that help with pain management. This means that CBD oil may benefit people with chronic pain, such as chronic back pain.

One 2008 review assessed how good CBD works to relieve chronic pain. The review looked at studies conducted between the late 1980s and 2007. Based on these reviews, researchers concluded CBD was effective in overall pain management without adverse side effects. They also noted that CBD was beneficial in treating insomnia related to chronic pain.

The authors of the study also noted that CBD was most helpful in people with multiple sclerosis (MS).

CBD for arthritis pain relief

A 2016 study looked at the use of CBD in rats with arthritis. Researchers applied CBD gel to rats for four days in a row. They applied 0.6, 3.1, 6.2, and 62.3 milligrams per day. The researchers noted reduced inflammation and overall pain in the rats’ affected joints without side effects.

The anti-inflammatory and pain-relieving effects of the CBD gel could hold promise for people with arthritis. However, more human studies are needed. ADVERTISING

CBD for cancer treatment relief

CBD oil is also used by some people who have cancer. A few studies in mice have shown a reduction of cancerous tumors. But most human studies have involved research into the role of CBD oil in managing pain related to cancer and cancer treatment. The National Cancer Institute (NCI) has pointed to CBD as a possible option for relieving symptoms caused by chemotherapy.

One study by the NCI tested CBD oil extracts sprayed into the mouth. The CBD oil was used in conjunction with opioids. This study revealed better pain management with the help of CBD oil. But more research is still needed.

CBD oil side effects

CBD oil doesn’t pose significant risks for users. However, side effects are possible. These include:

  • nausea
  • sleeping issues
  • irritability

Withdrawal symptoms are rare after you stop using it, and much rarer compared with addictive substances like opioids. Most withdrawal symptoms are related a return of the original symptoms of anxiety or pain.

The National Cancer Institute also warns against the use of CBD in children due to possible adverse effects on brain development.

Further research

Overall, researchers agree that while there isn’t conclusive data to support CBD oil as the preferred method of pain management, these types of products have a lot of potential. CBD products might be able to offer relief for many people who have chronic pain, all without causing intoxication and dependence. Oil versions of CBD may not be as effective as other forms, and more human studies are needed.

CBD oil is widely available through online outlets. It is also available in some clinics in places where its usage is legal.

CBD – The Good, the Bad and the Oily

Drug interactions are a significant consideration in modern medicine. More than half of U.S. adults regularly take prescription meds and at least 75 percent of Americans take at least one over-the-counter drug. Many people, including most seniors (the fastest growing demographic of cannabis users), take multiple drugs, and these compounds can interact and affect the metabolism of each other.

Several variables make precise predictions about drug interactions difficult, even for practiced physicians. “It is much easier to assess whether drug interactions are likely than to predict their exact effect,” the Project CBD primer asserts

To the extent that there have been problematic drug interactions with cannabinoids, these have involved high doses of nearly pure CBD isolates, not cannabis in general. Even though THC is an intoxicant and CBD is not, the fact that people tend to use much higher doses of pure CBD makes it a much riskier player in metabolic drug interactions.

Drug interactions are much more likely with high dose CBD therapy than other forms of cannabis consumption. Physicians and patients should be concerned about this, given that the current regulatory regime privileges CBD isolates over artisanal, plant-derived, multicomponent formulations.

How dangerous are cannabinoid-drug interactions? As dangerous as mis-dosing the other drug(s) that a patient is taking. Problems are more likely to arise when a patient combines a high dose of an otherwise benign CBD isolate with a pharmaceutical that has a very narrow window between its therapeutic and toxic levels.


CBD Oil and its Anti Inflammatory Components

Chronic low-level inflammation can severely erode your health; the silent lurker contributes to at least seven of the ten leading causes of mortality in the United States — which include heart disease, cancer, chronic lower respiratory disease, stroke, Alzheimer’s disease, diabetes, and nephritis.

While real organic food and proper nutrition should be the base of any anti-inflammatory protocol, CBD has shown to significantly suppress chronic inflammatory and neuropathic pain without causing dependency or tolerance

CBD Oil and Oxidative Stress

Do you suffer from an autoimmune disease , neurodegenerative disease, or cancer? Some studies have shown CBD oil to be effective in prevention and treatment.

Today, chronic disease is on the rise like never before, with oxidative stress playing a significant causative role. Oxidative stress occurs when the body has too many free radicals and can’t counteract the damage. People fall prey when eating a nutrient deficient diet or when they experience an onslaught of toxins and the body can’t keep up and detox, causing more symptoms of disease.  

How amazing that CBD is particularly beneficial in the treatment of oxidative stress-associated diseases of the CNS, because cannabinoids’ ability to cross the blood brain barrier and exert their antioxidant effects in the brain.

CBD OIL and Depression

A study published in the journal Pharmacology concluded  that CBD could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate cortical signalling through a 5-HT1A receptor-dependent mechanism.

 Another abstract published  in 2016Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.  concluded that CBD is effective for depression.

Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health. Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound. The aim of this study is to review studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound. Studies involving animal models, performing a variety of experiments on the above-mentioned disorders, such as the forced swimming test (FST), elevated plus maze (EPM) and Vogel conflict test (VCT), suggest that CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed. Experiments with CBD demonstrated non-activation of neuroreceptors CB1 and CB2. Most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.

How can CBD help with fibromyalgia?

Cannabidiol (CBD) is one of more than 100 chemical compounds derived from cannabis, a plant also known as marijuana. A small body of research suggests that cannabidiol may help people with fibromyalgia.

A review from 2013 states that cannabidiol (CBD) can help to relieve pain caused by fibromyalgia and other conditions, including rheumatoid arthritis and multiple sclerosis.

The United States Food and Drug Administration (FDA) has not approved the medicinal use of CBD for, although CBD received approval for use in treating two types of epilepsy in June 2018.

Research is ongoing, and the legal status of this and other cannabinoids varies. A person should check their local laws before attempting to obtain CBD.

Nonetheless, CBD remains a popular choice. In this article, we explore why CBD may be able to relieve the pain of fibromyalgia. We also examine its most effective use and potential side effects.

Is CBD the same as marijuana?

Cbd for fibromyalgia

CBD is one of many chemicals found in some strains of marijuana.

In short, CBD is not the same as marijuana. CBD is one of many chemicals found in some strains of the marijuana plant.

However, CBD is responsible for many of medical marijuana’s health benefits. More concentrated forms of CBD, such as cannabidiol oil, could offer greater benefits with fewer risks than using medical marijuana.

The compound in marijuana that gets users high is called tetrahydrocannabinol (THC). No evidence suggests that CBD can get a person high. This may make it a good option for people who:

  • want to abstain from marijuana use
  • have a history of bad reactions to marijuana
  • are uncomfortable using mind-altering substances
  • do not want to experience a high but still want to experience the health benefits

In recent years, there has been a surge of interest in administering CBD to children with epilepsy, because it is effective in reducing seizures that do not respond well to other medications.

How does CBD for fibromyalgia work?

Only a few studies have looked at the effectiveness of CBD in treating fibromyalgia.

Researchers cannot decisively say why the compound appears to reduce some fibromyalgia symptoms, but there are some strong theories that are still being tested in research.

They also do not understand why it works in some people and not in others.

The pain-relieving effects of CBD may be explained by the ways that this substance affects the brain. It may interrupt the nerve pathways that send signals of pain between the brain and the body.

There is also an anti-inflammatory action of CBD that would reduce heat and swelling around injury or disease. This, in turn. would reduce pain.

A 2016 study suggested that a lack of endocannabinoids — neurotransmitters that bind to cannabinoid receptors — may be at the root of chronic pain syndromes, including migraines and fibromyalgia. Taking CBD may correct this deficiency, explaining the compound’s success in alleviating chronic pain.

The Potential Benefits of CBD for the Symptoms of Bipolar Disorder

Your brain relies on neurotransmitters, in specific chemical combinations, to regulate your moods, thoughts, feelings, and behavior.

The driving force behind your system of neurotransmitters and their corresponding receptors is called your endocannabinoid system. Thanks to the discovery of the endocannabinoid system, researchers now have a better understanding of how brain chemicals interact and communicate, what happens when the communication system fails, and how to potentially restore the communication processes.

The Neurotransmitters that Influence Your Endocannabinoid System

Your body makes the neurotransmitters that regulate this vital system. They are called endocannabinoids because they are processed within. Your two main endocannabinoids are anandamide and 2-AG.

Your body also responds to exogenous cannabinoids, cannabinoids from an outside source. Exogenous cannabinoids are found in the extract (CBD) of the cannabis plants, hemp, and marijuana. Both plants are equally beneficial, but marijuana has high levels of THC (tetrahydrocannabinol) which is a psychoactive cannabinoid, hemp does not. You will not get high from hemp CBD oil.

The Many Functions of Your Endocannabinoid System

Exogenous cannabinoids mimic the effects of your endocannabinoids, interacting and communicating with receptors throughout your endocannabinoid system. Your endocannabinoid system is responsible for nearly every function and process in your body. Just some of the functions regulated by this system include:

  • Your moods and emotional responses
  • Stress responses and anxiety
  • Metabolism and energy
  • Neuroprotection and muscle movement
  • Memory and learning
  • Sleep cycles
  • Reproductive function
  • Pain perception and inflammation
  • Cardiovascular function

The endocannabinoids in your body are produced as needed and quickly broken down by enzymes. The exogenous cannabinoids from CBD are stronger and longer lasting.

The Potential Consequences of System Imbalance

Because your endocannabinoid system is crucial to so many vital functions, some researchers are suggesting that many health concerns could be the result of imbalances within the endocannabinoid system. This theory could explain why the research into supplementing the endocannabinoid system with CBD is showing so many potential benefits.

Research shows that CBD has the potential to alleviate pain, improve sleep, reduce inflammation,  and improve the symptoms of anxiety and depressive disorders, including bipolar affective disorder. While the study of the endocannabinoid system is relatively new, the results have been quite fascinating.

Understanding the Basics of Bipolar Disorders

Bipolar disorders cause marked changes in a persons mood, behavior, energy levels, and function. Those living with a bipolar disorder experience extreme, intense emotional states, referred to as mood episodes. Due to the complexity of the condition, bipolar disorder often goes undiagnosed or misdiagnosed as depression. Episodes of extreme emotion can be classified as manic, hypomanic or depressive.

Manic Episodes

A manic episode is a period where a person has more energy than usual. They may seem high-spirited, very happy, or irritable. During a manic episode, a person may sleep less, have racing thoughts or engage in risky behaviors, like spending sprees or reckless driving. A manic mood episode may be severe enough to cause problems with work, family, social relationships and interfere with responsible behavior. Manic episodes may also progress to paranoia, delusions or psychosis.

Hypomanic Episodes

Symptoms of hypomanic episodes are similar to manic episodes, though less severe. Hypomania does not cause as many potential problems as mania, and the person living with hypomania is typically still able to function.

Major Depressive Episodes

A depressive episode is classified as a period where a person has lost interest in activities they previously enjoyed, experiences feelings of hopelessness, worthlessness or guilt. During a depressive episode, a person may experience extreme fatigue and sleep disturbances. Concentration levels or decision-making processes may be impaired. Some may have thoughts of suicide or death.

The Medications Typically Used to Treat Bipolar Disorder

Some people living with bipolar disorder may only experience a few cycles of episodes in their entire lifetime, while others will cycle through both extremes of the disorder daily. Treatment typically involves a combination of support programs, psychiatric counseling, and possibly hospitalization to get a severe manic or depressive episode stabilized with medications.  Some of the medications typically used to treat the symptoms of bipolar disorder include:

  • Mood Stabilizers to control manic or hypomanic episodes (lithium, valproic acid, carbamazepine)
  • Antipsychotics- if manic symptoms or depression persist (Abilify, Zyprexa, Latuda)
  • Antidepressants – usually prescribed with a mood stabilizer to avoid triggering a manic episode
  • Anti depressant-antipsychotic – depression treatment with a mood stabilizer (Symbyax)
  • Anticonvulsants – to control manic episodes and depression ( Depakote, Tegretol)

While antidepressants, anticonvulsants and anti-psychotic medication are typically used for bipolar symptoms, finding the optimal combination of drugs can be tricky. Treating the symptoms of one aspect of the disorder can trigger the other. More than half of those living with bipolar do not feel that their medications alleviate their symptoms, many stop taking their medications.

Some give up taking medications because of the side effects, some for the high costs, and others because they believe they no longer need them. While many eventually return to taking prescription medications, some patients look to diet, exercise or supplementing their neurotransmitters and receptors with CBD from non-psychoactive hemp, for the potential benefits of mood stabilization.

The Potential Benefits of CBD for the Symptoms of Bipolar Disorder

While there are currently few studies on the use of CBD for bipolar disorder, CBD appears to generate the same type of response in the body as many of the medications used to treat the condition. The neuroprotective and antioxidative benefits of CBD may also help to alleviate the symptoms of bipolar and increase the levels of brain-derived neurotrophic factor levels.

It’s not difficult to find testimony from people living with bipolar disorder crediting CBD for relieving their symptoms, or reducing the side effects of their current medications. While testimonies are anecdotal, their findings appear to be backed by scientific evidence.

  • A federally funded research study neurologically assessed 133 patients diagnosed with bipolar disorder. The test subjects took 100 mg of CBD daily over the course of several weeks. All 133 participants reported feeling consistent energy levels throughout the day and stable mood levels. At the end of the study, their neurological tests were administered Each of the participants showed remarkable improvement in attention, verbal fluency, executive functioning and logical- memory recall.

Research also suggests that CBD appears to act similarly to atypical antipsychotic drugs without the potentially serious and long-term side effects, by providing anticonvulsant and mood-stabilizing benefits, similarly to the medications used to treat manic episodes. CBD is also shown to have value as a low-risk antidepressant that is unlikely to interfere with prescription medications.

CBD as a Natural Dietary Supplement

It’s important to remember that CBD is not a cure or treatment for any disorder. CBD is not a medication; it is a dietary supplement with the potential to supplement the neurotransmitters and influence the receptors that regulate your moods, emotions,  and nearly every important function regulated by your endocannabinoid system.

The information supporting the use of CBD from hemp is based on research results, animal studies and the testimonies of those who claim benefits from CBD supplements. If you have a medical condition or take medication, it is important to discuss the potential benefits of CBD with your healthcare provider. CBD is known to interact with some medications.

CBD May Promote Cognitive Function

Studies show that regular consumption of CBD may actually improve cognitive function. Many mental illnesses, such as depression, have to do with an imbalance of chemicals in the brain. Others directly impact one’s neurology.

In addition to the endocannabinoid system, cannabinoids in CBD oil also interact with the body’s central nervous system. CBD may promote healthy nerve function and stimulate healthy neuron firing and interaction.

As a result, individuals with mental illness who take CBD oil may experience clarity of mind and greater levels of rational thinking.

Many maintain that CBD oil may even foster a greater sense of self-awareness. This can be critical for people with mental illness who may feel at the mercy of their disorders.